SLUG (SNAI2) Rabbit Polyclonal Antibody

CAT#: TA306360

Rabbit Polyclonal Slug Antibody



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CNY 5,808.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1 - 2 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Slug antibody was raised against a 14 amino acid peptide from near the center of human Slug .
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name snail family transcriptional repressor 2
Background Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
Synonyms SLUG; SLUGH1; SNAIL2; WS2D
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adherens junction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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