TRAF2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TRAF2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TRAF2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TNF receptor associated factor 2
Database Link	NP_066961 Entrez Gene 22030 MouseEntrez Gene 311786 RatEntrez Gene 7186 Human UniProt ID Q12933
Background	Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress (1). TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity (2), and are critical for NF-kappaB activation in mouse B lymphocytes (3). TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells (4). TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac (5).
Synonyms	MGC:45012; TRAP; TRAP3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.