Beclin 1 (BECN1) Rabbit Polyclonal Antibody

CAT#: TA306256

Rabbit Polyclonal Beclin-1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Beclin-1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Beclin-1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name beclin 1
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6).
Synonyms ATG6; beclin1; VPS30
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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