Caspase-6 (CASP6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Caspase-6 antibody was raised against a 15 amino acid peptide from near the amino-terminus of human Caspase-6.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 6
Database Link	NP_001217 Entrez Gene 839 Human UniProt ID P55212
Background	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was idientifed based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).
Synonyms	MCH2
Reference Data
Protein Families	Druggable Genome, Protease, Stem cell - Pluripotency
Protein Pathways	Apoptosis

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