SARM (SARM1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	SARM antibody was raised against a peptide corresponding to amino acids near the C-terminus of human SARM.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Ion exchange chromatography purified
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name	sterile alpha and TIR motif containing 1
Database Link	NP_055892 Entrez Gene 237868 MouseEntrez Gene 23098 Human UniProt ID Q6SZW1
Background	Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
Synonyms	MyD88-5; SAMD2; SARM
Reference Data
Protein Families	Druggable Genome

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