ALS2CR2 (STRADB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 10 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ILPIP antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ILPIP.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	STE20-related kinase adaptor beta
Database Link	NP_061041 Entrez Gene 227154 MouseEntrez Gene 501146 RatEntrez Gene 55437 Human UniProt ID Q9C0K7
Background	ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family (1). Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1? converting enzyme of Fas-induced apotosis (1,2). This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival (3), suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
Synonyms	ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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