BACE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, IF, IHC, WB
Recommend Dilution	WB: 1 µg/mL; IHC-P: 2.5 µg/mL; ICC: 10 µg/mL; IF: 20 µg/mL. Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry, Immunocytochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	BACE antibody was raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.
Formulation	PBS containing 0.02% sodium azide.
Purification	BACE Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	beta-secretase 1
Database Link	AF190725 Entrez Gene 23621 Human UniProt ID P56817
Background	Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Synonyms	ASP2; BACE; HSPC104
Reference Data

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