IRAK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	IRAK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK2. The immunogen is located within amino acids 530 - 580 of IRAK-2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 1 receptor associated kinase 2
Database Link	AF026273 Entrez Gene 3656 Human UniProt ID O43187
Background	The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappaB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 . Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappaB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappaB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
Synonyms	IRAK-2
Reference Data

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