Bak (BAK1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.5-1µg/ml.
Reactivity	Human, Mouse, Rat, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence ASGQGPGPPRQE-C, from the N Terminus of the protein sequence according to NP_001179.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23.2 kDa
Gene Name	BCL2 antagonist/killer 1
Database Link	NP_001179 Entrez Gene 12018 MouseEntrez Gene 116502 RatEntrez Gene 578 Human UniProt ID Q16611
Background	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq]
Synonyms	BAK; BAK-LIKE; BCL2L7; CDN1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transmembrane

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