INSIG1 Rabbit Polyclonal Antibody
CAT#: TA301693
Rabbit Polyclonal Antibody against Insig1
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CNY 5,381.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | ICC/IF, WB |
Recommend Dilution | Western Blot: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503. |
Formulation | PBS + 30% glycerol and 0.1% sodium azide |
Concentration | lot specific |
Purification | Immunogen affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | insulin induced gene 1 |
Database Link | |
Background | Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Synonyms | CL-6; CL6 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
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