TRF2 (TERF2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, Dot, ELISA, FC, ICC/IF, IHC, IP, Simple Western, WB
Recommend Dilution	Knockdown Validated, Flow Cytometry: 1-5 ug/ml, Dot Blot, Western Blot: 1:2000 - 1:5000, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:200, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, ELISA, Immunoprecipitation: 1:10 - 1:500, Simple Western: 1:25, Immunohistochemistry: 1:200, Immunohistochemistry-Paraffin: 1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Baculovirus purified TRF2 protein.
Formulation	Tris-glycine, 150mM NaCl, 0.1% BSA. and 0.05% sodium azide
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	telomeric repeat binding factor 2
Database Link	NP_005643 Entrez Gene 7014 Human UniProt ID Q15554
Background	TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implied a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 may be oncogenic.
Synonyms	TRBF2; TRF2
Reference Data
Protein Families	Transcription Factors

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