HNRPM (HNRNPM) Mouse Monoclonal Antibody [Clone ID: 2A6]

Specifications

Product Data
Clone Name	2A6
Applications	ICC/IF, IHC, IP, Simple Western, WB
Recommend Dilution	Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen: 1:10-1:500, Simple Western: 1:3000
Reactivity	Human, Mouse, Rat, Bovine, Porcine, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	M19 fusion protein containing full-length human protein.
Formulation	Ascitic fluid and sodium azide
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	heterogeneous nuclear ribonucleoprotein M
Database Link	NP_112480 Entrez Gene 76936 MouseEntrez Gene 116655 RatEntrez Gene 4670 Human UniProt ID P52272
Background	Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
Synonyms	CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Spliceosome

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.