DERL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry: 5-10 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:2000, Western Blot: 1:1000-1:5000, Immunohistochemistry-Paraffin: 5-10 ug/ml
Reactivity	Human, Dog
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to the C-terminal region of the human Derlin-1 protein sequence (between residues 200-251).
Formulation	Tris-citrate/phosphate, pH 7-8, 0.1% sodium Azide
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	derlin 1
Database Link	NP_077271 Entrez Gene 475086 DogEntrez Gene 79139 Human UniProt ID Q9BUN8
Background	Derlin-1 is a channel-like protein, found in the ER membrane, responsible for degrading and funneling misfolded proteins and other cellular debris into the appropriate degradative pathways within the cell.
Synonyms	DER-1; DER1; derlin-1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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