FOXP3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Western Blot: 1:1000-1:5000, Immunohistochemistry-Paraffin: 1:200 - 1:1000, Immunohistochemistry-Frozen: 1:50, Immunohistochemistry: 1:50-1:1000, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Dual RNAscope ISH-IHC
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to the C-terminal region of human FOXP3 (between residues 400-431).
Formulation	Tris-citrate/phosphate [pH 7-8] and Sodium Azide
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	forkhead box P3
Database Link	NP_054728 Entrez Gene 50943 Human UniProt ID Q9BZS1
Background	FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
Synonyms	AIID; DIETER; IPEX; JM2; PIDX; XPID
Reference Data
Protein Families	Transcription Factors

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