Blnk Rabbit Polyclonal Antibody
CAT#: SP3004P
Blnk rabbit polyclonal antibody, Purified
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CNY 3,810.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western Blot: Resuspend approx. 50 mil. cells in 1 ml cold Lysis buffer (1% laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including Protease inhibitor Cocktail). Incubate 60 min on ice. Centrifuge to remove cell debris. Mix lysate with reducing Laemmli SDS-PAGE sample buffer. Application note: Reducing conditions. |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human BLNK |
Specificity | The antibody reacts with BLNK, a cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human BLNK). |
Formulation | PBS, pH 7.4, containing 15 mM sodium azide as preservative. State: Purified State: Liquid Serum |
Concentration | lot specific |
Purification | Precipitation methods; purity < 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | B cell linker |
Database Link | |
Background | SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa; B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase Cg2, as well as Grb2 and Nck adaptor proteins; thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways. |
Synonyms | BASH, SLP65, SLP-65 |
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