BAFF Receptor (TNFRSF13C) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot (2-5 µg/ml): Detects a band of approximately 20 kDa in Western blots of spleen lysates. Immunohistochemistry on Paraffin Sections: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within the C-terminus of Human CD268.
Specificity	This antibody is specific for CD268, also known as B cell activating factor receptor (BAFF-R).
Formulation	PBS containing 0.02% Sodium Azide as presrevative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily member 13C
Database Link	Entrez Gene 115650 Human UniProt ID Q96RJ3
Background	Members of the TNF superfamily regulate immune responses and induce apoptosis. BAFF-R (B cell activating factor receptor) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kappaB and c-jun N terminal kinase.
Synonyms	BAFF receptor, BLyS receptor 3, TNFRSF13C, BR3, BAFF-R
Reference Data

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