GAD67 (GAD1) (+ GAD2 / GAD65) Rabbit Polyclonal Antibody
CAT#: SP1218P
GAD67 (GAD1) (+ GAD2 / GAD65) rabbit polyclonal antibody, Purified
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CNY 11,363.00
货期*
4周
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommend Dilution | ELISA. Western Blot: 1/1000-1/10000. Immunohistochemistry on Frozen Sections: 1/200-1/5000. Recommended Positive Control: Brain. |
Reactivity | Feline, Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide sequence from the C-terminus of GAD |
Specificity | This antibody recognises both molecular forms of Glutamic Acid Decarboxylase (GAD65 and GAD67), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region. |
Formulation | PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. State: Purified State: Liquid purified Immunoglobulin-rich fraction. |
Purification | Ammonium Sulphate Precipitation. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | glutamate decarboxylase 1 |
Database Link | |
Background | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome. |
Synonyms | Glutamate decarboxylase 1, GAD-67 |
Note | Predicted Molecular Weight: 65 and 67 kDa. |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
---|
Russell-Like Bodies in Plant Seeds Share Common Features With Prolamin Bodies and Occur Upon Recombinant Protein Production
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Frontiers in Plant Science
,PubMed ID 31316529
[GAD1]
|
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