Carbonic Anhydrase II (CA2) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ID, WB
Recommend Dilution	Western Blot: 1/1000. Immunodiffusion.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Purified human carbonic anhydrase II (CAII) prepared from erythrocytes.
Specificity	Product identity is confirmed by double diffusion vs CAII. No reactivity is seen in immunodiffusion against CAI.
Formulation	Glycine buffered saline pH7.4 containing 0.09% Sodium Azide, 0.1% EACA, 1mM EDTA and 0.01% Benzamidine State: Purified State: Liquid purified IgG
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	carbonic anhydrase 2
Database Link	Entrez Gene 760 Human UniProt ID P00918
Background	Carbonic anhydrase II (CAII) is a single polypeptide chain of molecular weight 29kDa. It is present in the cytosol of most tissues, but highest concentrations are found, like Carbonic Anhydrase I, in erythrocytes. The concentration in erythrocytes is about 20µM. It catalyses the hydration of CO2 and the hydrolysis of esters. Zn2+ ion cofactor is required for enzyme activity. Certain point mutations occur without apparent clinical effect, however, complete absence leads to mild mental retardation and cerebral calcification, osteoporosis and renal tubular acidosis.
Synonyms	Carbonic anhydrase II, Carbonate dehydratase II, Carbonic anhydrase C, CA2, CA-II, CAC
Reference Data

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