Transferrin (TF) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ID
Recommend Dilution	Immunodiffusion: Use neat antibody. Successful use in Immunohistochemistry on Frozen Sections was reported by some researchers. As this detection method has not been verified by Acris Antibodies, the application was deleted from the database. This does not necessarily exclude the use in such procedure.
Reactivity	Feline, Guinea Pig, Human, Mouse, Rabbit, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	Human holo-Transferrin. Antisera to Human Transferrin were raised by repeated immunisation of Sheep with highly purified antigen.
Specificity	This antibody recognizes Transferrin, an iron binding glycoprotein of 79 kDa. Negative Species: Goat, Chicken, Bovine, Porcine, Canine, Horse.
Formulation	Glycine buffered saline, pH 7.4 with 0.09% Sodium Azide, 0.01% Benzamidine, 0.1% EACA and 1mM EDTA State: Purified State: Liquid purified IgG fraction
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	transferrin
Database Link	Entrez Gene 7018 Human UniProt ID P02787
Background	Iron saturated Human Holo Transferrin is a glycoprotein containing 679 amino acids. Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture. It is referred to frequently as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.
Synonyms	Serotransferrin, Siderophilin
Reference Data

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