SETD7 (1-366) Mouse Monoclonal Antibody [Clone ID: s4E5]

Specifications

Product Data
Clone Name	s4E5
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/500-1/2,000. Recommended Starting Dilution: 1/1,000. Immunohistochemistry on Paraffin Sections: 5 µg/ml after heat induced antigen retrieval in pH 6.0 citrate buffer. Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human SET7/9 protein (1-366aa) purified from E. coli
Specificity	The antibody recognizes Human SET7/9. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	SET domain containing lysine methyltransferase 7
Database Link	Entrez Gene 80854 Human UniProt ID Q8WTS6
Background	Set7/9 is a histone methyltransferase (HMTase) that transfers methyl group to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.
Synonyms	SET7, SET7/9, KMT7, KIAA1717
Note	Predicted Molecular Weight: 50 kDa.
Reference Data

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