CD8A Mouse Monoclonal Antibody [Clone ID: MEM-31]

CAT#: SM3102R

CD8A mouse monoclonal antibody, clone MEM-31, PE



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CNY 4,340.00


货期*
5周

规格
    • 100 Tests

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Specifications

Product Data
Clone Name MEM-31
Applications FC
Recommend Dilution Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
Does not work in Immunohistochemistry on paraffin sections or Western blot.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Crude thymus membrane fraction
Specificity The antibody recognizes a conformationally-dependent epitope of CD8 antigen.
Formulation Phosphate buffered saline (PBS) solution containing 15mM sodium azide
Label: PE
State: Liquid purified Ig fraction
Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation PE
Storage Condition Store at 2-8 °C. Do not freeze. Avoid prolonged exposure to light.
Gene Name CD8a molecule
Background The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Synonyms CD8 alpha chain, CD8A, MAL
Reference Data
Protein Families Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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