CD1 (CD1A) Mouse Monoclonal Antibody [Clone ID: HI149]

Specifications

Product Data
Clone Name	HI149
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human cells using 20 µl reagent / 100 ml of whole blood or 10e6 cells in a suspension.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human thymocytes
Specificity	The antibody reacts with CD1a (T6), a 49 KDa polypeptide associated with, b2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. Label: FITC State: Liquid purified Ig fraction Label: Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use
Conjugation	FITC
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD1a molecule
Database Link	Entrez Gene 909 Human UniProt ID P06126
Background	CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Synonyms	T6/Leu-6, hTa1
Reference Data

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