CD71 / TFRC Mouse Monoclonal Antibody [Clone ID: OX-26]

Specifications

Product Data
Clone Name	OX-26
Applications	FC
Recommend Dilution	Flow cytometry.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	PHA activated rat lymphocytes. Spleen cells from immunised Balb/c mice were fused with cells of the NS1 mouse myeloma cell line.
Specificity	This antibody recognises CD71, also known as transferrin receptor. Clone MRC OX-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Clone MRC OX-26 is reported as suitable for use in Electron Microscopy.
Formulation	PBS, pH7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin Label: PE State: Lyophilized purified IgG Label: R. Phycoerythrin (RPE)
Reconstitution Method	Restore with 1 ml distilled water
Purification	Affinity chromatography on protein G
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Database Link	UniProt ID Q99376
Background	CD71 is a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialised proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimers, Parkinsons, Huntingtons and Multiple Sclerosis.
Synonyms	TfR1, p90, Transferrin receptor protein 1
Reference Data

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