Junctional Adhesion Molecule 1 (F11R) Mouse Monoclonal Antibody [Clone ID: BV16]

CAT#: SM2041F

Junctional Adhesion Molecule 1 (F11R) mouse monoclonal antibody, clone BV16, FITC



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CNY 8,738.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name BV16
Applications FC, IF, IHC, WB
Recommend Dilution Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50.
Flow cytometry: The typical starting working dilution is 1:50.
Immunoflourescence.
Western blot: The typical starting working dilution is 1:50.
Does not work in Immunoprecipitation.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Fusion protein consisting of the extracellular domain of human JAM and the Fc portion of human IgGs
Specificity The monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A.
Formulation PBS
Label: FITC
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Potein G
Conjugation FITC
Storage Condition

Store at 2 - 8 °C.

Gene Name F11 receptor
Background Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis since JAM-A is upregulated on early atherosclerotic endothelium. The adhesion of activated platelets on the activated endothelium is mediated by homophilic interactions of JAM-A.
Synonyms JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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