CD180 / RP105 Rat Monoclonal Antibody [Clone ID: RP/14]
CAT#: SM1823F
CD180 / RP105 rat monoclonal antibody, clone RP/14, FITC
Conjugation: Biotin
Need it in bulk or conjugated?
Get a free quote
CNY 6,000.00
货期*
5周
规格
Product images
Specifications
Product Data | |
Clone Name | RP/14 |
Applications | FC |
Recommend Dilution | Flow cytometry: The typical starting working dilution is 1:50. |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Specificity | This antibody detects Radioprotective 105 (RP105, CD180). |
Formulation | PBS Label: FITC State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | lot specific |
Purification | Protein G |
Conjugation | FITC |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | CD180 antigen |
Database Link | |
Background | Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105. |
Synonyms | LY64 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...