CD46 Mouse Monoclonal Antibody [Clone ID: MEM-258]

CAT#: SM1819AF

CD46 mouse monoclonal antibody, clone MEM-258, Azide Free



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CNY 3,280.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Clone Name MEM-258
Applications FC, IP, WB
Recommend Dilution Flow cytometry: 1 µg/ml.
Immunoprecipitation.
Western blot (Non-reducing conditions).
Reactivity Bovine, Human
Host Mouse
Clonality Monoclonal
Immunogen HPB-ALL human T cell line
Specificity This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Formulation Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
State: Azide Free
State: Liquid Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name CD46 molecule
Background CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
Synonyms TLX, MIC10
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Complement and coagulation cascades
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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