CD45 Mouse Monoclonal Antibody [Clone ID: CA12.10C12]

Specifications

Product Data
Clone Name	CA12.10C12
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on frozen sections.
Reactivity	Canine
Host	Mouse
Clonality	Monoclonal
Specificity	This antiboyd recognises the homologue of CD45. Clone CA12.10C12 recognises a glycoprotein of approximately 200kD which is expressed by cells of haemapoietic origin.
Formulation	containing 0.09% Sodium Azide State: Supernatant State: Liquid Tissue Culture Supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms	Leukocyte common antigen, L-CA, PTPRC, T200, LCA
Reference Data

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