CDK4 Mouse Monoclonal Antibody [Clone ID: DCS-31.2]

Specifications

Product Data
Clone Name	DCS-31.2
Applications	IHC, IP, WB
Recommend Dilution	Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises cyclin dependent kinase 4 (Cdk4). Clone DCS 31.2 does not cross react with other cdks and does not co-precipitate the D type cyclins bound to cdk4.
Formulation	PBS containing 0.08% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cyclin-dependent kinase 4
Database Link	Entrez Gene 1019 Human UniProt ID P11802
Background	Cdk4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. Cdk4 is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1/S phase, which is controlled by the regulatory subunits D type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). The mutations in this gene as well as its related proteins including D type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Two alternatively spliced variants, and multiple polyadenylation sites of this gene have been reported.
Synonyms	PSK-J3
Reference Data

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