CD89 (FCAR) Mouse Monoclonal Antibody [Clone ID: MIP8a]

Specifications

Product Data
Clone Name	MIP8a
Applications	ELISA, FC, IP, WB
Recommend Dilution	ELISA. Western Blot. Immunoprecipitation. Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 10e6 cells or 100 µl whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant soluble Human Fc alpha R
Specificity	This antibody recognises the CD89 cell surface antigen. Clone MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes. The preservative free format of this antibody (product code SM1198A) is recommended for functional studies.
Formulation	PBS containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Fc fragment of IgA receptor
Database Link	Entrez Gene 2204 Human UniProt ID P24071
Background	CD89 cell surface antigen is a 50-70kD glycoprotein that is also known as the IgA receptor. CD89 is expressed by peripheral blood neutrophils and monocytes. Human CD89 is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody dependent cell mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types.
Synonyms	IgA Fc receptor
Reference Data

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