CD59 Mouse Monoclonal Antibody [Clone ID: MEM-43]

Specifications

Product Data
Clone Name	MEM-43
Applications	FC
Recommend Dilution	Flow Cytometry (Neat).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The antigen binds to C8 and C9 and inhibits assembly of the complement membrane attack complex.
Formulation	BS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. Label: FITC State: Liquid purified IgG fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD59 molecule
Database Link	Entrez Gene 966 Human UniProt ID P13987
Background	CD59 is an LY6 like protein expressed in human lymphoid cells (haemapoietic and non- haemapoietic cells), regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 is an 18-20kD GPI anchored single chain glycoprotein, expressed by virtually all cell types, including leucocytes, platelets and erythrocytes.
Synonyms	MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20
Reference Data

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