CD51 (ITGAV) Mouse Monoclonal Antibody [Clone ID: 23C6]

Specifications

Product Data
Clone Name	23C6
Applications	FC, IP
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/40-1/80  diluted antibody to label 10e6 cells in 100 µl. Immunoprecipitation. Immunohistochemistry on frozen sections: use Aceton as fixative, Formaldehyde will destroy the epitope
Reactivity	Chicken, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Osteoclasts from osteoclastomas. Spleen cells from immunised mice were fused with cells of the mouse X63.Ag8.653 myeloma cell line.
Specificity	This antibody recognises the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. 23C6 reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha V
Database Link	Entrez Gene 3685 Human UniProt ID P06756
Synonyms	ITGB3, ITGB-3, GP3A, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, Integrin beta-3, ITGAV, MSK8, VNRA, Vitronectin receptor subunit alpha, CD51, Integrin alpha-V, Vitronectin Receptor
Reference Data

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