CD45 (PTPRC) (CD45RO) Mouse Monoclonal Antibody [Clone ID: UCHL1]

Specifications

Product Data
Clone Name	UCHL1
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections. Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Recommended Positive Control: Tonsil or lymph node.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Interleukin-2-dependent Human T lymphocytes.
Specificity	UCHL-1 reacts with mature activated T cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. Shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. It rarely stains B cell lymphomas. Cellular Localization: Membranous.
Formulation	State: Supernatant State: Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	protein tyrosine phosphatase, receptor type C
Database Link	Entrez Gene 9332 HumanEntrez Gene 5788 Human UniProt ID P08575
Background	CD45RO is a single chain transmembraneous glycoprotein which represents the low molecular weight isoform of the Leucocyte Common Antigen (LCA). It expressed on most thymocytes, monocytes, macrophages and granulocytes. It is not expressed on normal B lymphocytes. Intrathymic T cell maturation progresses from CD45RA-/CD45RO+ to CD45RA+/CD45RO-; while peripheral T cell maturation progresses from CD45RA+/CD45RO- to CD45RA-/CD45RO+.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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