CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: AK2]

Specifications

Product Data
Clone Name	AK2
Applications	ELISA, FC, FN, IP
Recommend Dilution	ELISA. Immunoprecipitation. Functional Assays. Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 100 µl whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antiboydy recognises the Human CD42b cell surface antigen, also known as platelet glycoprotein GP1B. Clone AK2 has been reported to block the binding of von Willebrand Factor (VWF) to platelets (Ref.1).
Formulation	PBS, pH 7.2 without preservatives State: Low Endotoxin State: Liquid purified IgG fraction Stabilizer: None
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glycoprotein Ib platelet alpha subunit
Database Link	Entrez Gene 2811 Human UniProt ID P07359
Background	CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF. CD42b is expressed by platelets and megakaryocytes.
Synonyms	Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha
Reference Data

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