Cd40lg Hamster Monoclonal Antibody [Clone ID: 39H5]

Specifications

Product Data
Clone Name	39H5
Applications	FC
Recommend Dilution	Flow Cytometry: use 10 µl of neat antibody to label 10e6 cells in 100 µl.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	L cells transfected with CD40L.
Specificity	This antibody recognises the CD154 cell surface antigen.
Formulation	PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. Label: FITC State: Liquid purified IgG fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD40 ligand
Database Link	Entrez Gene 21947 Mouse UniProt ID P27548
Background	CD154 is a 39kD cell surface glycoprotein also known as CD40 ligand. CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L.
Synonyms	CD40 ligand, CD40-L, CD40LG, TNFSF5, TRAP, GP39
Reference Data

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