Cd8a Rat Monoclonal Antibody [Clone ID: YTS105.18]

CAT#: SM024P

Cd8a rat monoclonal antibody, clone YTS105.18, Purified



Need it in bulk or conjugated?
Get a free quote

CNY 6,116.00


货期*
4周

规格
    • 250 ug

Product images

Specifications

Product Data
Clone Name YTS105.18
Applications FC, IHC
Recommend Dilution Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 10e6 cells in 100 µl.
Immunohistochemistry on Frozen Sections.
Reactivity Mouse
Host Rat
Clonality Monoclonal
Immunogen Mouse spleen cells.
Spleen cells from an immunised DA rat were fused with cells of the rat Y3/Ag1.2.3. myeloma cell line.
Specificity This antibody recognises a non polymorphic epitope on the CD8 alpha chain.
Blocks MHC I dependent T cell responses in vitro and in vivo, and induces transplantation tolerance in combination with CD4 antibodies.
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide as preservative.
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity Chromatography on Protein G.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name CD8 antigen, alpha chain
Background CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds. It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.
Synonyms CD8 alpha chain, CD8A, MAL
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...