ZNF148 Rabbit Polyclonal Antibody

CAT#: R1493

ZNF148 rabbit polyclonal antibody, Serum



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CNY 8,025.00


货期*
4周

规格
    • 100 ul

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Specifications

Product Data
Applications ELISA, WB
Recommend Dilution This polyclonal antibody reacts human ZBP-89 in a variety of immunological assays including western blot and ELISA. This antibody is likely functional in immunohistochemistry and immunoprecipitation.
Recommended dilutions
Immunoblotting: 1:5,000. A band at approximately 89 kDa corresponding to human ZBP-89 is detected. Human monocytes or macrophages or nuclear extracts from PMA treated U937 cells can be used as a positive control.
ELISA: 1:10,000 - 1:30,000.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Purified full length ZBP-89 recombinant protein expressed in E.coli
Specificity This polyclonal antibody is specific for ZBP-89.
Formulation State: Serum
State: Liquid (sterile filtered) Ig fraction containing 0.09% (w/v) Sodium Azide
Concentration lot specific
Purification Delipidation and defibrination
Conjugation Unconjugated
Storage Condition Store the antibody undiluted (in aliquots) at -20°C.
Avoid cycles of freezing and thawing.
Gene Name zinc finger protein 148
Background The GI tract abundantly expresses growth factors many of which bind and activate the EGF receptor present on mucosal cells. One such factor is the zinc finger protein (ZBP-89) that binds to a GC-rich DNA element in the gastrin promoter and confers EGF responsiveness. The fulllength protein functions as a repressor of growth factor signals regulating the gastrin promoter. Several other growth related promoters are also regulated by ZBP-89. ZBP-89 is one of a family of related transcriptional regulators. It has been reported in recent studies that ZBP-89 regulates growth in part by stimulating the cyclin-dependent kinase inhibitor, p21waf1, in a butyrate-dependent manner through recruitment of the histone acetyl transferase p300. Moreover, ZBP-89 triggers growth arrest in a p53-dependent manner by preventing nuclear export of p53. ZBP-89 also induces apoptosis, but this process occurs independent of p53.
Synonyms ZBP89
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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