Lep Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant rat Leptin (E. coli).
Specificity	This antibody reacts to Leptin.
Formulation	0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE State: Aff - Purified State: Lyophilized purified IgG
Reconstitution Method	Restore with 0.1 ml of deionized water
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C. Avoid repeated freezing and thawing.
Gene Name	leptin
Database Link	Entrez Gene 25608 Rat UniProt ID P50596
Background	Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa proteohormone consisting of 146 amino acid residues. Leptin is produced by differentiated adiocytes, although production have been demonstrated in other tissues, such as fundus of the stomach, the sceletal muscle, the liver, and the placenta. Leptin is considered to play an important role in appetite control, fat metabolism and body weight regulation. It targets the central nervous system, in particular the hypothalamus, suppressing food intake and stimulating energy expenditure. In humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are elevated even in obese individuals. Leptin has a dual action; it decreases the appetite and increases energy consumption, causing more fat to be burned.
Synonyms	LEP, OB, OBS, Obesity factor, Obese protein
Reference Data

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