Her2 (ERBB2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin embedded sections: diluted of 1:25-1:50 in an ABC method (30 minutes at room temperature) Although not required, high temperature treatment may enhance the immunostaining in overfixed tissues. Recommended Positive Control: Breast carcinoma
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Keyhole limpet hemocyanin conjugated synthetic human peptide c-erbB-2 oncoprotein.
Specificity	This antibody reacts with the c-erbB-2 oncoprotein, a 190 kD protein. Cellular Localization: Cell membrane
Formulation	containing azide as preservative. State: Purified State: Liquid purified antiserum
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	erb-b2 receptor tyrosine kinase 2
Database Link	Entrez Gene 2064 Human UniProt ID P04626
Background	The proto-oncogene for c-erbB-2 is located on the human chromosome 17, band 21. It has structural similarities to EGFR. Several studies have indicated that c-erbB-2 may be a good indicator of the prognosis of human carcinomas in the breast, ovary, uterus and gastrointestinal tract.
Synonyms	HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19
Reference Data

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