MSH6 Mouse Monoclonal Antibody [Clone ID: 44]

CAT#: DM429

MSH6 mouse monoclonal antibody, clone 44, Supernatant



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CNY 10,669.00


货期*
4周

规格
    • 1 ml

Cited in 2 publications.

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Specifications

Product Data
Clone Name 44
Applications IHC, IP, WB
Recommend Dilution Immunoprecipitation.
Western Blot: 1/100-1/500.
Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABC method (30 to 60 minutes at room temperature (requires high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining).
Immunohistochemistry on Frozen Sections.
Recommended Positive Control: Tonsil, colon carcinoma
Reactivity Canine, Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Synthetic human MSH6 peptide
Specificity MSH6 is a heterodimer of MSH2 binds to DNA containing G/T mismatches.
The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.
Cellular Localization: Nuclear.
Formulation State: Supernatant
State: Liquid purified Ig fraction containing Sodium Azide as preservative.
Purification Affinity Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name mutS homolog 6
Background An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
Synonyms DNA mismatch repair protein Msh6, GTBP
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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