Thyroid Peroxidase (TPO) Mouse Monoclonal Antibody [Clone ID: MoAb47]

Specifications

Product Data
Clone Name	MoAb47
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin embedded sections: diluted of 1:10-1:25 in an ABC method (30-60 minutes at room temperature) Positive Control: Thyroid
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Thyroid Peroxidase (hTPO) purified from thyroid microsomes by immunoaffinity chromatography.
Specificity	Reacts to Thyroid Peroxidase. Cellular Localization: Cytoplasmic
Formulation	1mM EDTA buffer, pH 9.0 - containing sodium azide as preservative. State: Supernatant State: Liquid tissue culture supernatant
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroid peroxidase
Database Link	Entrez Gene 7173 Human UniProt ID P07202
Background	Thyroid Peroxidase (TPO) is a transmembrane protein of 107kD containing a heme prosthetic group and it is present as dimmer on the apical surface of the thyroid follicular cells. TPO is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may be useful aid in the differentiation between the benign and malignant thyroid tumors.
Synonyms	MSA; OTTHUMP00000115536; TDH2A; thyroperoxidase; TPX
Reference Data

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