VEGFA (Isoform 165) Mouse Monoclonal Antibody [Clone ID: 7G7]

Specifications

Product Data
Clone Name	7G7
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: Use at 1-2 µg/ml. Western blot: Use at 1-5 µg/ml. Immunofluorescence. Immunohistochemistry: Use at 1-10 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human VEGF165 protein (45 kDa) Cat.-No DA3514X
Specificity	The antibody recognizes Human VEGF-A. Other species not tested.
Formulation	PBS, pH 7.4 without preservative or stabilizer State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored lyophilized at RT for up to 1 month or at -20°C long term.
Gene Name	vascular endothelial growth factor A
Database Link	Entrez Gene 7422 Human UniProt ID P15692
Background	VEGFA is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternate transcriptional splice variants, encoding either freely secreted or cell associated isoforms, have been characterized. There is also evidence for the use of non AUG (CUG) translation initiation sites upstream of, and in frame with the first AUG, leading to additional isoforms.
Synonyms	VEGFA, VEGF, VPF, Vascular endothelial growth factor A, Vascular permeability factor
Reference Data

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