VEGF Receptor 1 (FLT1) Mouse Monoclonal Antibody [Clone ID: FLTEWF]
CAT#: DM3506B
VEGF Receptor 1 (FLT1) mouse monoclonal antibody, clone FLTEWF, Biotin
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CNY 4,585.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | FLTEWF |
Applications | ELISA, IF, IP, WB |
Recommend Dilution | ELISA (1-10 µg/ml). Western blotting (1-10 µg/ml). Immunofluorescence. Immunoprecipitation (2-10 µg/ml lysate or reaction volume). |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant Human soluble extracellular Flt-1 protein (D5) (Cat.-No DA3539) |
Specificity | The unconjugated monoclonal antibody will recognize recombinant and naturally occurring form of VEGFR-1/Flt-1. |
Formulation | PBS Label: Biotin State: Lyophilized purified IgG fraction Stabilizer: 50X BSA Preservative: 0.02% Sodium Azide |
Reconstitution Method | Restore with distilled sterile water to a concentration of 0.1-1.0 mg/ml. |
Purification | Protein G Chromatography |
Conjugation | Biotin |
Storage Condition | Prior to reconstitution store at 2-8°C. |
Gene Name | fms related tyrosine kinase 1 |
Database Link | |
Background | Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. |
Synonyms | VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1 |
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