VEGF Receptor 1 (FLT1) Mouse Monoclonal Antibody [Clone ID: FLTEWF]

CAT#: DM3506B

VEGF Receptor 1 (FLT1) mouse monoclonal antibody, clone FLTEWF, Biotin



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CNY 4,585.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Clone Name FLTEWF
Applications ELISA, IF, IP, WB
Recommend Dilution ELISA (1-10 µg/ml).
Western blotting (1-10 µg/ml).
Immunofluorescence.
Immunoprecipitation (2-10 µg/ml lysate or reaction volume).
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Human soluble extracellular Flt-1 protein (D5) (Cat.-No DA3539)
Specificity The unconjugated monoclonal antibody will recognize recombinant and naturally occurring form of VEGFR-1/Flt-1.
Formulation PBS
Label: Biotin
State: Lyophilized purified IgG fraction
Stabilizer: 50X BSA
Preservative: 0.02% Sodium Azide
Reconstitution Method Restore with distilled sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Protein G Chromatography
Conjugation Biotin
Storage Condition

Prior to reconstitution store at 2-8°C.
Following reconstitution store undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name fms related tyrosine kinase 1
Background Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Synonyms VEGFR1, FLT1, FLT, FRT, VEGF Receptor 1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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