Collagen IV (COL4A1) Mouse Monoclonal Antibody [Clone ID: COL-94]

Specifications

Product Data
Clone Name	COL-94
Applications	IHC
Recommend Dilution	Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted of 1:25-1:50 in an ABC method (30 minutes at room temperature) Recommended Positive Control: Skin
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human collagen type IV.
Specificity	This antibody recognizes collagen type IV epitope located on the alpha1 and/or alpha 2 chains of human collagen type IV. This antibody shows no cross reactivity with collagen types I, II, III, V, VI and VII as well as does not react with human vitronectin, fibronectin or chondroitin sulfate A, B and C. Cellular Localization: Basement membrane
Formulation	State: Ascites State: Ascites containing Sodium Azide as preservative.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	collagen type IV alpha 1 chain
Database Link	Entrez Gene 1282 Human UniProt ID P02462
Background	Collagen IV is a major constituent of the basement membranes along with laminins, proteoglycans and enactins. It is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. It can form insoluble fibers with high tensile strength. Collagen IV is useful in detecting the loss of parts of basement membranes in carcinomas.
Synonyms	COL4A1
Reference Data
Protein Pathways	ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

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