MCP1 (CCL2) Mouse Monoclonal Antibody [Clone ID: 9G10]

Specifications

Product Data
Clone Name	9G10
Applications	ELISA, FN
Recommend Dilution	ELISA: React with Human MCP-1. Neutralizing: Tests on the ability to inhibit monocyte chemotaxis toward 1 nM recombinant human MCP-1 in blindwell chambers showed that the antibodies were particularly effective on blocking MCP1 activity.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant Human MCP1.
Specificity	This MCP1 antibody reacts with natural and recombinant Human MCP-1. Does not react with Human Interleukin-8 (IL-8) and other human cytokines tested such as interleukin-1 beta (IL1 beta), serum Amyloid A (SAA) and epidermal growth factor (EGF).
Formulation	0.01M PBS, pH 7.2 without preservatives. State: Azide Free State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with double distillated water to adjust the final concentration to 1.00 mg/ml
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine ligand 2
Database Link	Entrez Gene 6347 Human UniProt ID P13500
Background	This chemotactic factor attracts monocytes and basophils but not neutrophils or eosinophils and augments monocyte anti-tumor activity. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Synonyms	C-C motif chemokine 2, SCYA2, MCAF, Small-inducible cytokine A2, MCP-1, HC11, HC-11
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

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