Tartrate Resistant Acid Phosphatase (ACP5) Mouse Monoclonal Antibody [Clone ID: TRAP-01]

Specifications

Product Data
Clone Name	TRAP-01
Applications	ELISA
Recommend Dilution	Enzyme Immunoassay.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TRAP 5 expressed in Sf9 cells.
Specificity	The Anti Human TRAP 5 Antibody, Clone: TRAP-01 is a mouse monoclonal antibody against TRAP 5.
Formulation	0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE State: Purified State: Lyophilized purified IgG fraction Preservative: None
Reconstitution Method	Restore with 1 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration	lot specific
Purification	Affinity Chromatography on Immobilized Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	acid phosphatase 5, tartrate resistant
Database Link	Entrez Gene 54 Human UniProt ID P13686
Background	TRAP 5 (serum band 5 tartrate-resistant acid phosphatase, TRACP 5; EC 3.1.3.2) is a glycoprotein of 35-37 kDa. TRAP 5 belongs to the most abundant enzymes in osteoclasts. It is expressed in certain differentiated cells of the mononuclear phagocyte system, particularly osteoclasts and alveolar macrophages, where it takes an active part in bone resorption process. High blood levels of TRAP 5 are usually associated with active bone remodelling. Increased serum levels are observed during normal bone growth among healthy children. Elevated serum TRAP levels have been detected in diseases characterized by increased bone resorption; Pagets disease of the bone, hemodialysis, primary hyperparathyroidism, metastatic malignancies involving bone resorption, multiple myeloma and bilaterally ovariectomized women. Post-menopausal women have higher levels of serum than post-menopausal women on estrogen replacement therapy. Therefore specific determination of TRAP 5 activity can be essential for clinical assessment of bone metabolism.
Synonyms	Tartrate-resistant acid phosphatase type 5, TRAP5, TRAcP
Reference Data

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