Osteoprotegerin (TNFRSF11B) Mouse Monoclonal Antibody [Clone ID: OPG-13]

Specifications

Product Data
Clone Name	OPG-13
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic OPG peptide that comprises AA21 to AA39 homologous with human osteoprotegerin (N-terminal C has been added to the peptide)
Specificity	The Anti Human Osteoprotegerin, Clone: OPG-13 is a mouse monoclonal antibody against synthetic peptide of Human Osteoprotegerin.
Formulation	0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE State: Aff - Purified State: Lyophilized purified IgG
Reconstitution Method	Restore with 0.1 ml of deionized water
Concentration	lot specific
Purification	Affinity chromatography on protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily member 11b
Database Link	Entrez Gene 4982 Human UniProt ID O00300
Background	Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.
Synonyms	OPG, OCIF
Reference Data

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