Fibronectin (FN1) Mouse Monoclonal Antibody [Clone ID: 568]

Specifications

Product Data
Clone Name	568
Applications	IHC, IP, R, WB
Recommend Dilution	Immunoblotting. Cell preparations. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections (after microwave treatment). Working Dilutions: 1/5-1/10. Incubation time: 1 h at room temperature. Recommended Positive Control: Human skin, ulcerating tissue.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	High molecular weight proteins secreted by cultivated Human fibroblasts.
Specificity	This antibody 568 reacts with the cell binding part of the Fibronectin molecule. Fibronectin seems to play a key role in the tumor cell extracellular matrix during in-vasive tumor growth. Increasing expression of stro-mal fibronectin has been reported during tumor pro-gression. In immunohistochemistry the antibody is reactive with an extracellular matrix glycoprotein in vessels and connective tissue.
Formulation	PBS State: Supernatant State: Liquid Culture Supernatant Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	fibronectin 1
Database Link	Entrez Gene 2335 Human UniProt ID P02751
Background	Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours.
Synonyms	FN1, Cold-insoluble globulin, CIG
Reference Data

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