CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: Y2/51]

Specifications

Product Data
Clone Name	Y2/51
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/100-1/200 diluted antibody to label 10e6 cells in 100 µl. Immunohistochemistry on Frozen and Paraffin Sections: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin prior to staining. Western Blotting: Detects a band/s of approximately 90kDa in platelet lysates.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PHA stimulated peripheral blood cells. Spleen cells from immunised Balb/c mice were fused with cells of the NS1 myeloma cell line.
Specificity	This antibody recognises CD61.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin subunit beta 3
Database Link	Entrez Gene 3690 Human UniProt ID P05106
Background	CD61 is a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.
Synonyms	Integrin beta-3, GP3A, GPIIIa
Reference Data

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