Actin (ACTA1) Mouse Monoclonal Antibody [Clone ID: 5C5]

Specifications

Product Data
Clone Name	5C5
Applications	IHC
Recommend Dilution	This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. Suitable for formalin/paraffin tissues. We suggest an incubation period of 30 minutes at room temperature. Recommended positive control: skeletal muscle.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified rabbit striated muscle actin
Specificity	This antibody is specific to alpha-skeletal and alpha-cardiac muscle actins. Monoclonal anti-alpha-sarcomeric Actin has been used as a marker for rhabdomyosarcoma. Cellular localization: cytoplasmic.
Formulation	State: Supernatant State: Diluted ascites containing sodium azide as preservative.
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8°C.
Gene Name	actin, alpha 1, skeletal muscle
Database Link	Entrez Gene 58 Human UniProt ID P68133
Background	The two major cytoskeletal proteins implicated in cell motility are actin and myosin. Actin and myosin are constituents of many cell types and are involved in a myriad of cellular processes including locomotion, secretion, cytoplasmic streaming, phagocytosis and cytokinesis. Although actin is one of the most conserved eukaryotic proteins, it is expressed in mammals and birds as at least six isoforms characterized by electrophoresis and amino acid sequence analysis. Four of them represent the differentiation markers of muscle tissues and two are found in practically all cells.
Synonyms	ACTA; Alpha-actin-1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
Reference Data

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