IL13 receptor alpha 1 (IL13RA1) (Extracell. Dom.) Mouse Monoclonal Antibody [Clone ID: GM1E7]
CAT#: DM1227
IL13 receptor alpha 1 (IL13RA1) (Extracell. Dom.) mouse monoclonal antibody, clone GM1E7, Purified
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CNY 5,660.00
货期*
5周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Clone Name | GM1E7 |
Applications | ELISA, FC, IF |
Recommend Dilution | Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 µg/106 cells. Immunofluorescence: 1 µg/106 cells. Specific inhibition of IL-13-dependent proliferation of TF-1 cells by GM-1E7 (See Figure.3). |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Genetic immunization with cDNA encoding Human IL13-R alpha 1 (extracellular domain). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells. |
Specificity | Recognizes IL13 Receptor (IL13-R). |
Formulation | Phosphate buffered saline, pH 7.2 without preservatives State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein G |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Gene Name | interleukin 13 receptor subunit alpha 1 |
Database Link | |
Background | Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Ra1 together with IL-4Ra forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation |
Synonyms | Interleukin-13 receptor alpha-1 chain, IL-13R-alpha-1, IL-13RA-1, IL13R, IL13RA, IL13 receptor alpha, CT19 |
Note | SDS-PAGE analysis: The antibody was purified by Protein G Affinity Chromatography from cell culture supernatants and verified by SDS-Page (Figure.4). |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1
,Krause S, Behrends J, Borowski A, Lohrmann J, Lang S, Myrtek D, Lorenzen T, Virchow JC, Luttmann W, Friedrich K,
Mol. Immunol.
,PubMed ID 16364441
[IL13RA1]
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